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Vaccine. 2011 Mar 21;29(14):2568-75. doi: 10.1016/j.vaccine.2011.01.059. Epub 2011 Feb 5.

Aerosol vaccination induces robust protective immunity to homologous and heterologous influenza infection in mice.

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1
College of Veterinary Medicine, Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.

Abstract

Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding similar protection with lower doses. We evaluated 20 and 30 μm aerosol delivery of influenza virus in mice. A 15s aerosol exposure optimally protected against homologous and heterologous influenza infection and induced a robust immune response. These results demonstrate the feasibility of nasal vaccination using aerosolized particles, providing a strategy to improve vaccine efficacy and delivery.

PMID:
21300100
PMCID:
PMC3076080
DOI:
10.1016/j.vaccine.2011.01.059
[Indexed for MEDLINE]
Free PMC Article
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