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Laryngoscope. 2011 Apr;121(4):873-8. doi: 10.1002/lary.21416. Epub 2011 Feb 4.

Olfactory impairment in older adults: five-year incidence and risk factors.

Author information

1
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA. Schubert@episense.wisc.edu

Abstract

OBJECTIVES/HYPOTHESIS:

The objective of this study was to determine the five-year incidence of olfactory impairment and associated risk factors in a general population of older adults.

STUDY DESIGN:

Longitudinal population-based study.

METHODS:

Participants (n = 1,556) in the population-based Epidemiology of Hearing Loss Study had olfaction measured at the 5- and 10-year examinations (1998-2000 and 2003-2005, respectively). Olfactory ability was measured by the San Diego Odor Identification Test.

RESULTS:

The five-year incidence of olfactory impairment was 12.5%. Incidence rates increased with age for men and women. In a multivariate model, age (odds ratio [OR] = 1.79, 95% CI, 1.61-2.00; for every five-year increase), a history of nasal polyps (OR = 2.33, 95% CI, 1.13-4.59), a history of deviated septum (OR = 2.05, 95% CI, 1.14-3.56), and a history of heavy alcohol use (OR = 1.84, 95% CI, 1.13-2.93) were associated with an increased risk of olfactory impairment, whereas use of lipid-lowering agents (OR = 0.68, 95% CI, 0.46-0.99; yes vs. no), exercising at least once a week (OR = 0.69, 95% CI, 0.48-0.98), and oral steroid use (OR = 0.37, 95% CI, 0.11-0.94) were associated with a decreased risk.

CONCLUSIONS:

The five-year incidence of olfactory impairment is high in this population of older adults. Modifiable risk factors associated with impairment suggest some impairment could be amenable to prevention or treatment.

PMID:
21298645
PMCID:
PMC3063862
DOI:
10.1002/lary.21416
[Indexed for MEDLINE]
Free PMC Article

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