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Org Biomol Chem. 2011 Apr 7;9(7):2185-91. doi: 10.1039/c0ob00755b. Epub 2011 Feb 7.

Synthesis of functionalized arylpyridines and -pyrimidines by domino [4+2]/retro [4+2] cycloadditions of electron-rich dienes with alkynylpyridines and -pyrimidines.

Author information

1
Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059, Rostock, Germany.

Abstract

Aryl-substituted pyridines and pyrimidines were prepared by [4+2] cycloadditions of alkynyl-substituted pyridines and -pyrimidines with electron-rich dienes. The reactions proceed by formation of a bridged cycloadduct and subsequent thermal extrusion of ethylene. The pyridine moiety plays a crucial role for the success of the reaction.

PMID:
21298164
DOI:
10.1039/c0ob00755b
[Indexed for MEDLINE]

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