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Biochim Biophys Acta. 2011 Jun;1813(6):1137-43. doi: 10.1016/j.bbamcr.2011.01.033. Epub 2011 Feb 4.

The role and therapeutic potential of prohibitin in disease.

Author information

  • 1Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA. arianne.theiss@baylorhealth.edu

Abstract

Prohibitin 1 (PHB1), a pleiotropic protein in the cell, has been implicated in the regulation of proliferation, apoptosis, transcription, mitochondrial protein folding, and as a cell-surface receptor. This diverse array of functions of PHB1 is attributed to the cell type studied and its subcellular localization. This review discusses recent data that indicate a diverse role of PHB1 in disease pathogenesis and suggest that targeting PHB1 may be a potential therapeutic option for treatment of diseases including cancer, inflammatory bowel disease, insulin resistance/type 2 diabetes, and obesity. These diseases are associated with increased oxidative stress and mitochondrial dysfunction and therefore, the role of PHB1 in both responses will also be discussed.

PMID:
21296110
PMCID:
PMC3370678
DOI:
10.1016/j.bbamcr.2011.01.033
[PubMed - indexed for MEDLINE]
Free PMC Article
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