L-type calcium channel auto-regulation of transcription

Cell Calcium. 2011 May;49(5):306-13. doi: 10.1016/j.ceca.2011.01.001. Epub 2011 Feb 3.

Abstract

L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Calcium / metabolism
  • Calcium Channels, L-Type / chemistry
  • Calcium Channels, L-Type / genetics
  • Calcium Channels, L-Type / metabolism*
  • Cell Nucleus / metabolism
  • Gene Expression Regulation*
  • Humans
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / metabolism
  • Promoter Regions, Genetic
  • Protein Structure, Tertiary
  • Transcription, Genetic*

Substances

  • Calcium Channels, L-Type
  • Calcium