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Int J Biochem Cell Biol. 2011 May;43(5):701-4. doi: 10.1016/j.biocel.2011.01.020. Epub 2011 Feb 2.

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics.

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School of Life Sciences & State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610064, China.


It is well-known that cell cycle arrest and/or death play a pivotal role in tumor progression, which has drawn a rising attention for cancer biologists due to their complex and intricate relationships. In this review, we demonstrate the recent research on oridonin, an active diterpenoid with remarkable anti-proliferative activities, and then further explore its molecular mechanisms of cell cycle arrest, apoptosis, autophagy and their cross-talks in various cancer cells, which may provide a new perspective of oridonin as a candidate anti-neoplastic drug for future cancer therapeutics.

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