Format

Send to

Choose Destination
Virol J. 2011 Feb 4;8:50. doi: 10.1186/1743-422X-8-50.

The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin.

Author information

1
Department of Microbiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan.

Abstract

BACKGROUND:

Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.

RESULTS:

We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.

CONCLUSIONS:

These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.

PMID:
21294904
PMCID:
PMC3045344
DOI:
10.1186/1743-422X-8-50
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center