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J Am Chem Soc. 2011 Mar 2;133(8):2556-66. doi: 10.1021/ja108028m. Epub 2011 Feb 4.

Development and applications of fluorogenic probes for mercury(II) based on vinyl ether oxymercuration.

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1
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Abstract

Mercury is a major threat to the environment and to human health. It is highly desirable to develop a user-friendly kit for on-site mercury detection. Such a method must be able to detect mercury below the threshold levels for drinking water, 1-2 ppb. We developed a fluorescence method based on the oxymercuration of vinyl ethers to detect mercury in dental and environmental samples. Chloride ions interfered with the oxymercuration reaction, but the addition of AgNO(3) solved this problem. Fine electronic and structural tuning led to the development of a more responsive probe that was less sensitive to chloride ion interference. This second-generation probe could detect 1 ppb mercury ions in water.

PMID:
21294513
PMCID:
PMC3045475
DOI:
10.1021/ja108028m
[Indexed for MEDLINE]
Free PMC Article
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