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Int J Gynecol Pathol. 2011 Mar;30(2):193-7. doi: 10.1097/PGP.0b013e3181fceffc.

Two cases of adenosquamous carcinoma of the cervix with extensive in situ and invasive endometrial extension.

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Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, The University of Sydney, Sydney, NSW, Australia.


Adenosquamous carcinoma of the cervix is rare. It is defined as having both glandular and squamous cell differentiation, each component malignant and clearly seen on haematoxylin and eosin-stained slides alone. We report two cases of adenosquamous carcinoma of the uterine cervix, both of which showed in situ and invasive components and both of which showed cephalad extension to involve the endometrium with invasive squamous and adenocarcinomatous components. The mechanisms for cephalad endomyometrial extension is discussed, as are the potential implications for management and staging.

[Indexed for MEDLINE]

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