Format

Send to

Choose Destination
See comment in PubMed Commons below
Postgrad Med. 2011 Jan;123(1):34-44. doi: 10.3810/pgm.2011.01.2243.

The pharmacological treatment and management of obesity.

Author information

1
Department of Diabetes, Endocrinology, and Metabolism, Hammersmith Hospital, Imperial College London, London, UK.

Abstract

Obesity is a pandemic with many complications that increase the societal disease burden and cost of health care, and decrease longevity and quality of life. Currently, 1 in 3 adults in the United States is obese. Physicians must therefore regularly confront obesity and its consequent diseases, and develop strategies for effective treatment and management. This article summarizes current lifestyle modifications, pharmacological treatment, and surgical options for the management of obesity and discusses the benefits, limitations, and risks of each. As insights are gained into the pathophysiology of a gut-brain neurochemical feedback axis governing satiety and feeding behavior, targets for new pharmacotherapies are being developed. In particular, gut hormone analogs are an attractive antiobesity therapy because they appear to lack the adverse effects historically associated with central nervous system-acting agents.

PMID:
21293082
DOI:
10.3810/pgm.2011.01.2243
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center