Format

Send to

Choose Destination
Curr Opin Neurobiol. 2011 Apr;21(2):299-305. doi: 10.1016/j.conb.2011.01.002. Epub 2011 Feb 1.

The influence of synaptic activity on neuronal health.

Author information

1
Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

Abstract

According to the theory of neuronal health, neurons exist in a spectrum of states ranging from highly resilient to vulnerable. An unhealthy neuron may be rendered dysfunctional or non-viable by an insult that would ordinarily be non-toxic to a healthy neuron. Over the years it has become clear that a neuron's health is subject to dynamic regulation by electrical or synaptic activity. This review highlights recently identified activity dependent signalling events that boost neuronal health through the transcriptional control of pro-apoptotic and anti-apoptotic genes, the enhancement of antioxidant defences, and the regulation of mitochondrial and neurotrophic factor availability. Furthermore, activity dependent signals have recently been shown to influence a variety of events specific to individual neurodegenerative diseases, which will also be highlighted.

PMID:
21292474
PMCID:
PMC3160470
DOI:
10.1016/j.conb.2011.01.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center