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Virology. 2011 Mar 15;411(2):362-73. doi: 10.1016/j.virol.2010.12.045. Epub 2011 Feb 2.

Complement and viral pathogenesis.

Author information

1
Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Abstract

The complement system functions as an immune surveillance system that rapidly responds to infection. Activation of the complement system by specific recognition pathways triggers a protease cascade, generating cleavage products that function to eliminate pathogens, regulate inflammatory responses, and shape adaptive immune responses. However, when dysregulated, these powerful functions can become destructive and the complement system has been implicated as a pathogenic effector in numerous diseases, including infectious diseases. This review highlights recent discoveries that have identified critical roles for the complement system in the pathogenesis of viral infection.

PMID:
21292294
PMCID:
PMC3073741
DOI:
10.1016/j.virol.2010.12.045
[Indexed for MEDLINE]
Free PMC Article

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