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Mol Cell. 2011 Feb 4;41(3):243-4. doi: 10.1016/j.molcel.2011.01.016.

Ultrasensitivity and positive feedback to promote sharp mitotic entry.

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1
Institut de Biologie Moléculaire et Cellulaire, 1 Rue Laurent Fries, 67400 Illkirch Cedex, France.

Abstract

In this issue, Trunnell et al. (2011) show that in mitotic entry the positive feedback that drives the activation of cyclin-dependent kinase (Cdk) involves a very ultrasensitive step of phosphorylation of Cdc25C by Cdk, thus strongly contributing to the switch-like behavior of this essential cell-cycle transition.

PMID:
21292155
DOI:
10.1016/j.molcel.2011.01.016
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