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Mol Biol (Mosk). 2010 Nov-Dec;44(6):966-79.

[Chromatin structure and transcription regulation in Saccharomyces cerevisiae].

[Article in Russian]


Nucleosome organization of eukaryotic chromatin determines the DNA availability for regulatory factors during transcription. Nucleosome positioning at promoters is an important factor effecting gene expression. Recent studies showed that yeast promoters can be divided in two groups with the different chromatin organization. It has become clear that genes with the similar chromatin structure in promoters are regulated by the same mechanisms. In this review, using Saccharomyces cerevisiae as example, we discuss interplay between chromatin structure and transcription, dynamic changes in chromatin during transcription and a role of various factors (histone chaperones, remodeling complexes, histone variant H2A.Z) in these processes.

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