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Genes Dev. 2011 Feb 1;25(3):220-5. doi: 10.1101/gad.607011.

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage.

Author information

1
INSERM U563, Institut Claudius Regaud, Toulouse, France.

Abstract

Following DNA damage, mRNA 3'-end formation is inhibited, contributing to repression of mRNA synthesis. Here we investigated how DNA-damaged cells accomplish p53 mRNA 3'-end formation when normal mechanisms of pre-mRNA 3'-end processing regulation are inhibited. The underlying mechanism involves the interaction between a G-quadruplex structure located downstream from the p53 cleavage site and hnRNP H/F. Importantly, this interaction is critical for p53 expression and contributes to p53-mediated apoptosis. Our results uncover the existence of a specific rescue mechanism of 3'-end processing regulation allowing stress-induced p53 accumulation and function in apoptosis.

PMID:
21289067
PMCID:
PMC3034896
DOI:
10.1101/gad.607011
[Indexed for MEDLINE]
Free PMC Article

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