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Eur J Gastroenterol Hepatol. 2011 Mar;23(3):286-8. doi: 10.1097/MEG.0b013e328344042d.

Tylosis A with squamous cell carcinoma of the oesophagus in a Spanish family.

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Gastroenterology Service, Complexo Hospitalario Universitario de A Coruña, Spain.


Palmoplantar tylosis is a focal nonepidermolytic palmoplantar hyperkeratosis, which is inherited as an autosomal dominant condition. Two types have been described: an early onset type B tylosis, which occurs in the first year of life and is usually benign, and type A tylosis, which occurs between the ages of 5 and 15 years. Type A tylosis has been associated with a high incidence of oesophageal carcinoma in three families in England, Germany and the USA. This study describes an additional family from Spain with tylosis A, without any known relation to those described before.

[Indexed for MEDLINE]

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