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Vet Pathol. 2011 Nov;48(6):1151-7. doi: 10.1177/0300985811398246. Epub 2011 Feb 1.

Lyme neuroborreliosis in 2 horses.

Author information

1
Center of Comparative Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.

Abstract

Lyme neuroborreliosis--characterized as chronic, necrosuppurative to nonsuppurative, perivascular to diffuse meningoradiculoneuritis--was diagnosed in 2 horses with progressive neurologic disease. In 1 horse, Borrelia burgdorferi sensu stricto was identified by polymerase chain reaction amplification of B burgdorferi sensu stricto-specific gene targets (ospA, ospC, flaB, dbpA, arp). Highest spirochetal burdens were in tissues with inflammation, including spinal cord, muscle, and joint capsule. Sequence analysis of ospA, ospC, and flaB revealed 99.9% sequence identity to the respective genes in B burgdorferi strain 297, an isolate from a human case of neuroborreliosis. In both horses, spirochetes were visualized in affected tissues with Steiner silver impregnation and by immunohistochemistry, predominantly within the dense collagenous tissue of the dura mater and leptomeninges.

PMID:
21285382
DOI:
10.1177/0300985811398246
[Indexed for MEDLINE]

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