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J Transl Med. 2011 Jan 27;9 Suppl 1:S4. doi: 10.1186/1479-5876-9-S1-S4.

Natural anti-CCR5 antibodies in HIV-infection and -exposure.

Author information

1
Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy. lopalco.lucia@hsr.it

Abstract

Natural antibodies constitute a first-line of defence against pathogens; they may also play other roles in immune regulation and homeostasis, through their ability to bind host antigens, surface molecules and receptors. Natural anti-CCR5 antibodies can be decisive in preventing HIV infection in mucosal tissues and offer prompt and effective protection just at major sites of virus entry. Among natural anti-CCR5 antibodies, IgG and IgA to the ECL1 domain have been shown to block HIV effectively and durably without causing harm to the host. Their biological properties and their uncommon generation in subsets of HIV-infected and HIV-exposed individuals (so called ESN) will be introduced and discussed, with the aim at exploiting their potential in therapy and prevention.

PMID:
21284903
PMCID:
PMC3105504
DOI:
10.1186/1479-5876-9-S1-S4
[Indexed for MEDLINE]
Free PMC Article
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