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Antimicrob Agents Chemother. 2011 Apr;55(4):1754-7. doi: 10.1128/AAC.01049-10. Epub 2011 Jan 31.

Positive impact of HIV-1 gag cleavage site mutations on the virological response to darunavir boosted with ritonavir.

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1
AP-HP, Groupe Hospitalier Bichat-Claude Bernard, Laboratoire de Virologie, 75018 Paris, France.

Abstract

We assessed the roles of baseline gag and gag-pol cleavage site mutations (CSM) on the virological outcome of a darunavir-based regimen in highly antiretroviral-experienced patients. We showed the association, in multivariate analysis, between the A431V gag CSM and the virological response, defined as a reduction in plasma HIV-1 RNA to <50 copies/ml at month 3 (P = 0.028). Our results suggest that a specific gag CSM might have a role on protease inhibitor susceptibility in an inhibitor-specific manner.

PMID:
21282435
PMCID:
PMC3067137
DOI:
10.1128/AAC.01049-10
[Indexed for MEDLINE]
Free PMC Article
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