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J Biomed Opt. 2011 Jan-Feb;16(1):015004. doi: 10.1117/1.3528658.

Iris as a reflector for differential absorption low-coherence interferometry to measure glucose level in the anterior chamber.

Author information

1
Tsinghua University, Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen, 518055, China.

Abstract

We present a method of glucose concentration detection in the anterior chamber with a differential absorption optical low-coherent interferometry (LCI) technique. Back-reflected light from the iris, passing through the anterior chamber twice, was selectively obtained with the LCI technique. Two light sources, one centered within (1625 nm) and the other centered outside (1310 nm) of a glucose absorption band were used for differential absorption measurement. In the eye model and pig eye experiments, we obtained a resolution glucose level of 26.8 mg∕dL and 69.6 mg∕dL, respectively. This method has a potential application for noninvasive detection of glucose concentration in aqueous humor, which is related to the glucose concentration in blood.

PMID:
21280906
PMCID:
PMC4570116
DOI:
10.1117/1.3528658
[Indexed for MEDLINE]
Free PMC Article

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