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Proteomics Clin Appl. 2011 Feb;5(1-2):9-23. doi: 10.1002/prca.201000058. Epub 2010 Nov 11.

CE-MS in biomarker discovery, validation, and clinical application.

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Mosaiques Diagnostics & Therapeutics, Hannover, Germany.


CE coupled MS (CE-MS) has become an increasingly employed technology in proteome analysis with focus on the identification of biomarker peptides in clinical proteomics. In this review, we will cover technical aspects of CE-MS coupling and highlight the improvements made in the last few years. We examine CE-MS from an application point of view, and evaluate its merits and vices for biomarker discovery and clinical applications. We discuss the principal theoretical and practical obstacles encountered when employing CE-MS (and most other proteomic technologies) for the analysis of body fluids for biomarker discovery. We will present several examples of a successful application of CE-MS for biomarker discovery, implications for disease diagnosis, prognosis, and therapy evaluation, and will discuss current challenges and possible future improvements.

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