Format

Send to

Choose Destination
J Mol Med (Berl). 2011 Jun;89(6):537-43. doi: 10.1007/s00109-011-0727-5. Epub 2011 Jan 29.

Is CaMKII a link between inflammation and hypertrophy in heart?

Author information

1
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, 52242, USA. madhu-singh@uiowa.edu

Abstract

Myocardial infarction is a major cause of morbidity and mortality in the developing and developed world. Although current interventions have been successful in prolonging life, they are inadequate because mortality is still high among MI patients. The multifunctional Ca(2+)/calmodulin-dependent protein kinase (CaMKII) plays a key role in the structure and contractility of the myocardium. CaMKII activity is increased in MI hearts and CaMKII promotes cardiac hypertrophy and inflammation, processes consistently activated by myocardial injury. Hypertrophy and inflammation are also related to neurohumoral and redox signaling which uncouple CaMKII activation from Ca(2+)/calmodulin dependence. Thus, CaMKII may act as a nodal point for integrating hypertrophic and inflammatory signaling in myocardium.

PMID:
21279501
PMCID:
PMC3731449
DOI:
10.1007/s00109-011-0727-5
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center