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Drug Discov Today Dis Mech. 2010 Summer;7(2):e95-e102.

Regulation of mitochondrial processes: a target for heart failure.

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Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174.


Cardiac mitochondria, the main source of energy as well as free radicals, are vital organelles for normal functioning of the heart. Mitochondrial number, structure, turnover and function are regulated by processes such as mitochondrial protein quality control, mitochondrial fusion and fission and mitophagy. Recent studies suggest that abnormal changes in these mitochondrial regulatory processes may contribute to the pathology of heart failure (HF). Here we discuss these processes and their potential as therapeutic targets.

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