Format

Send to

Choose Destination
Oncogene. 2011 May 19;30(20):2304-6. doi: 10.1038/onc.2010.641. Epub 2011 Jan 31.

Commentary. A picture of Mitf in melanoma immortality.

Author information

1
Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK.

Abstract

The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis.

PMID:
21278792
DOI:
10.1038/onc.2010.641
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center