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Nat Neurosci. 2011 Mar;14(3):297-9. doi: 10.1038/nn.2751. Epub 2011 Jan 30.

Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory.

Author information

1
Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.

Abstract

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

PMID:
21278730
PMCID:
PMC3064406
DOI:
10.1038/nn.2751
[Indexed for MEDLINE]
Free PMC Article

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