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Life Sci. 2011 Mar 14;88(11-12):486-92. doi: 10.1016/j.lfs.2011.01.010. Epub 2011 Jan 26.

Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model.

Author information

1
Department of Food and Nutrition, Sookmyung Women's University, Seoul, 140-742, Republic of Korea.

Abstract

AIMS:

Aloe has been a very popular folk remedy for inflammation-related pathological conditions despite the lack of studies reporting its efficacy in vivo. The present study evaluated the anti-inflammatory effects of aloe components (aloin, aloesin and aloe-gel) known to be biologically active in the rat model of colitis.

MAIN METHODS:

Male Sprague Dawley rats were fed experimental diets for 2 weeks before and during the induction of colitis. Drinking water containing 3% dextran sulfate sodium (DSS) was provided for 1 week to induce colitis. At the end of the experimental period, clinical and biochemical markers were compared.

KEY FINDINGS:

Plasma leukotriene B(4) (LTB(4)) and tumor necrosis factor-α (TNF-α) concentrations were significantly decreased in all groups supplemented with aloe components compared to the colitis control group (p<0.05). Animals fed both a 0.1% and 0.5% aloesin supplemented diet showed colonic myeloperoxidase (MPO) activities which were decreased by 32.2% and 40.1%, respectively (p<0.05). Colonic mucosa TNF-α and interleukin-1ß (IL-1β) mRNA expressions were significantly reduced in all animals fed aloin, aloesin, or aloe-gel (p<0.05).

SIGNIFICANCE:

Dietary supplementation of aloe components ameliorates intestinal inflammatory responses in a DSS-induced ulcerative colitis rat model. In particular, aloesin was the most potent inhibitor. Further studies are required for a more complete understanding of the specific mechanism of the action of these supplements.

PMID:
21277867
DOI:
10.1016/j.lfs.2011.01.010
[Indexed for MEDLINE]

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