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Curr Opin Immunol. 2011 Apr;23(2):265-71. doi: 10.1016/j.coi.2011.01.002. Epub 2011 Feb 1.

Epidemiologic perspective on immune-surveillance in cancer.

Author information

1
Obsterics-Gynecology Epidemiology Center, Department of Obsterics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA. dcramer@partners.org

Abstract

Common 'themes' in epidemiology related to cancer risk beg a comprehensive mechanistic explanation. As people age, risk for cancer increases. Obesity and smoking increase the risk for many types of cancer. History of febrile childhood diseases lowers the risk for melanomas, leukemias, non-Hodgkin's lymphoma (NHL), and ovarian cancer. Increasing number of ovulatory cycles uninterrupted by pregnancies correlate positively with breast, endometrial, and ovarian cancer risk while pregnancies and breastfeeding lower the risk for these cancers as well as cancers of the colon, lung, pancreas, and NHL. Chronic inflammatory events such as endometriosis or mucosal exposure to talc increase the risk for several types of cancer. Mechanisms so far considered are site specific and do not explain multiple associations. We propose that most of these events affect cancer immunosurveillance by changing the balance between an effective immune response and immune tolerance of an emerging cancer. We review recently published data that suggest that immune mechanisms underlie most of these observed epidemiologic associations with cancer risk.

PMID:
21277761
PMCID:
PMC3073666
DOI:
10.1016/j.coi.2011.01.002
[Indexed for MEDLINE]
Free PMC Article

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