Format

Send to

Choose Destination
Drug Alcohol Depend. 2011 Jul 1;116(1-3):203-10. doi: 10.1016/j.drugalcdep.2010.12.018. Epub 2011 Feb 1.

The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine.

Author information

1
Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA.

Abstract

BACKGROUND:

Methamphetamine's behavioral effects have been attributed to its interaction with monoamine transporters; however, methamphetamine also has affinity for sigma receptors.

METHOD:

The present study investigated the effect of the sigma receptor agonist SA 4503 and the sigma receptor antagonists BD-1047 and BD-1063 on methamphetamine-evoked [(3)H]dopamine release from preloaded rat striatal slices. The effect of SA 4503 on methamphetamine-induced hyperactivity and on the discriminative stimulus properties of methamphetamine also was determined.

RESULTS:

SA 4503 attenuated methamphetamine-evoked [(3)H]dopamine release in a concentration-dependent manner. BD-1047 and BD-1063 did not affect release. SA 4503 dose-dependently potentiated and attenuated methamphetamine-induced hyperactivity. SA 4503 pretreatment augmented the stimulus properties of methamphetamine.

CONCLUSIONS:

Our findings indicate that SA 4503 both enhances and inhibits methamphetamine's effects and that sigma receptors are involved in the neurochemical, locomotor stimulatory and discriminative stimulus properties of methamphetamine.

PMID:
21277708
PMCID:
PMC3105201
DOI:
10.1016/j.drugalcdep.2010.12.018
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center