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Appl Radiat Isot. 2011 Apr;69(4):663-9. doi: 10.1016/j.apradiso.2011.01.006. Epub 2011 Jan 8.

Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core.

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Radiopharmacy Center, Institute of Energetic and Nuclear Research, Sao Paulo, SP, Brazil.


The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. The statistical routine was based on three-level factorial design. Best labeling conditions were achieved. The specific activity reached was 5 MBq/μg.

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