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Bioorg Med Chem Lett. 2011 Mar 1;21(5):1545-8. doi: 10.1016/j.bmcl.2010.12.096. Epub 2011 Jan 6.

Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists.

Author information

1
Department of Medicinal Chemistry, Almirall, Barcelona, Spain. daniel.perez@almirall.com

Abstract

The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β(1)/β(2)-adrenergic activities and the corresponding structure-activity relationship (SAR). We have focused on lipophilicity and duration of action, and we have discovered a strong correlation in this series of molecules. A quantitative structure-activity relationship (QSAR) analysis will be presented that quantifies this relationship.

PMID:
21277205
DOI:
10.1016/j.bmcl.2010.12.096
[Indexed for MEDLINE]

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