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Curr Opin Genet Dev. 2011 Jun;21(3):302-9. doi: 10.1016/j.gde.2011.01.007. Epub 2011 Jan 27.

The genetics of Tourette disorder.

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  • 1Department of Child Psychiatry, Yale University School of Medicine, New Haven, CT 06520, United States.


Tourette disorder (TD) is a childhood onset neuropsychiatric syndrome defined by persistent motor and vocal tics. Despite a long-standing consensus for a strong genetic contribution, the pace of discovery compared to other disorders of similar prevalence has been slow, due in part to a paucity of studies and both clinical heterogeneity and a complex genetic architecture. However, the potential for rapid progress is high. Recent rare variant findings have pointed to the importance of copy number variation, the overlap of risks among distinct diagnostic entities, the contribution of novel molecular mechanisms, and the value of family based studies. Finally, analysis of a cohort of sufficient size to identify common polymorphisms of plausible effect is underway, promising key information regarding the contribution of common alleles to TD.

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