Format

Send to

Choose Destination
AIDS Res Hum Retroviruses. 1990 Nov;6(11):1247-50.

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees.

Author information

1
Merck, Sharp and Dohme Research Laboratories, West Point, PA 19486.

Abstract

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus.

PMID:
2127681
DOI:
10.1089/aid.1990.6.1247
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center