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Int J Med Microbiol. 2011 Apr;301(4):318-24. doi: 10.1016/j.ijmm.2010.11.005. Epub 2011 Jan 26.

ICEVchInd5 is prevalent in epidemic Vibrio cholerae O1 El Tor strains isolated in India.

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Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, Via dei Sardi 70, 00185 Rome, Italy.


Integrative conjugative elements (ICEs) of the SXT/R391 family are self-transmissible mobile elements mainly involved in antibiotic resistance spread among ╬│-Proteobacteria, including Vibrio cholerae. We demonstrated that the recently described ICEVchInd5 is prevailing in V. cholerae O1 clinical strains isolated in Wardha province (Maharashtra, India) from 1994 to 2005. Genetic characterization by ribotyping and multiple-locus SSR analysis proved the same clonal origin for V. cholerae O1 isolates in Wardha province over an 11-year period and was used to assess the correlation between strain and ICE content among ours and different Indian reference strains. In silico analysis showed the existence of at least 3 sibling ICEs of ICEVchInd5 in V. cholerae O1 El Tor reference strains, isolated in the Indian subcontinent after 1992.

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