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Clin Nutr. 2011 Jun;30(3):376-83. doi: 10.1016/j.clnu.2010.11.006. Epub 2011 Jan 26.

Diet induced thermogenesis, fat oxidation and food intake following sequential meals: influence of calcium and vitamin D.

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Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, WA, Australia.



The mechanisms linking dietary calcium and vitamin D to body weight regulation require confirmation.


Eleven subjects, aged (mean ± SEM) 54 ± 1.2 y and BMI 31 ± 2.4 kg/m(2), participated in a randomised within-subject, sequential meal protocol comparing a low calcium trial (LCT) to an isoenergetic high calcium trial (HCT). Diet induced thermogenesis (DIT), fat oxidation rates (FOR), serum leptin, subjective feelings of hunger/satiety were measured at fasting and hourly over 8 h. Spontaneous food intake at a buffet and over the following 30 h was recorded. Postprandial responses, calculated as change (Δ) from baseline for each meal, were analysed by paired t-tests and 2 × 2 repeated measures ANOVA.


HCT resulted in lesser suppression of ΔFOR (p = 0.02) and a significantly greater DIT (p = 0.01). Further, the buffet to dinner interval was prolonged (p = 0. 083) and reported 24 h energy intake following this trial was significantly reduced (p = 0.017). ∆leptin following HCT but not LCT was negatively related to 24 h fat intake (r = -0.81, p = 0.016).


Higher calcium and vitamin D intake at a breakfast meal acutely increased postprandial FOR and DIT over two successive meals, and reduced spontaneous energy intake in the subsequent 24 h period. Australian New Zealand Clinical Trials Registry (ANZCTR) number: ACTRN12609000418279.

[Indexed for MEDLINE]

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