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Psychopharmacology (Berl). 2011 Jun;215(4):733-7. doi: 10.1007/s00213-011-2175-x. Epub 2011 Jan 29.

Exploring the relationship between vitamin D and basic personality traits.

Author information

1
Department of Physiology, University of Tuebingen, Gmelinstr. 5, 72076, Tuebingen, Germany.

Abstract

RATIONALE:

Several studies suggest an association between hypovitaminosis D and basic and executive cognitive functions, depression, bipolar disorder, and schizophrenia. A recent study confirms neophobic responses in vitamin D receptor mutant mice. We explored whether the plasma levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)), the active form of vitamin D, are correlated with basic personality traits.

METHODS:

A total of 206 healthy unrelated volunteers (108 male, 98 female, age 31 ± 13 years) completed the German version of the NEO Five-Factor Inventory (NEO-FFI), which allows reliable and valid assessment of personality along the dimensions neuroticism, extraversion, openness to new experiences, agreeableness and conscientiousness.

RESULTS:

We found a significant correlation between 1,25(OH)(2)D(3) concentration and the factor extraversion (n = 206, r = 0.202, p = 0.004) and the factor openness (n = 206, r = 0.148, p = 0.034).

CONCLUSION:

The possible mechanisms by which 1,25(OH)(2)D(3) acts on the brain might include Ca(2+) signaling, buffering antioxidant, and anti-inflammatory defenses against vascular injury, stimulating neurotrophins and improving metabolic and cardiovascular function. In conclusion, we suggest that 1,25(OH)(2)D(3) might influence personality traits, promoting extrovert and open behavior.

PMID:
21274699
DOI:
10.1007/s00213-011-2175-x
[Indexed for MEDLINE]

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