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J Obstet Gynaecol Can. 2011 Jan;33(1):46-48. doi: 10.1016/S1701-2163(16)34772-7.

The fetal safety of benzodiazepines: an updated meta-analysis.

Author information

1
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto ON; Department of Clinical Pharmacy, University of Benin, Nigeria.
2
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto ON.

Erratum in

  • J Obstet Gynaecol Can. 2011 Apr;33(4):319.

Abstract

Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.

PMID:
21272436
DOI:
10.1016/S1701-2163(16)34772-7
[Indexed for MEDLINE]

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