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Ann N Y Acad Sci. 2011 Jan;1216:122-37. doi: 10.1111/j.1749-6632.2010.05899.x.

Pharmacological enhancement of drug cue extinction learning: translational challenges.

Author information

1
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA. kkantak@bu.edu

Abstract

Augmentation of cue exposure (extinction) therapy with cognitive-enhancing pharmacotherapy may constitute a rational strategy for the clinical management of drug relapse. While certain success has been reported for this form of therapy in anxiety disorders, in this paper we highlight several obstacles that may undermine the efficacy of exposure therapy for substance use disorders. We also review translational studies that have evaluated the facilitative effects of the cognitive enhancer D-cycloserine on extinction targeting drug-related cues. Finally, important considerations for the design and implementation of future studies evaluating exposure therapy combined with pharmacotherapy for substance use disorders are discussed.

PMID:
21272016
PMCID:
PMC3064474
DOI:
10.1111/j.1749-6632.2010.05899.x
[Indexed for MEDLINE]
Free PMC Article

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