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Ann N Y Acad Sci. 2011 Jan;1216:99-113. doi: 10.1111/j.1749-6632.2010.05893.x.

The epigenetic landscape of addiction.

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  • 1Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.

Abstract

Drug-induced alterations in gene expression throughout the reward circuitry of the brain are likely components of the persistence of the drug-addicted state. Recent studies examining the molecular mechanisms controlling drug-induced transcriptional, behavioral, and synaptic plasticity have indicated a direct role for chromatin remodeling in the regulation and stability of drug-mediated neuronal gene programs, and the subsequent promulgation of addictive behaviors. In this review, we discuss recent advances in our understanding of chromatin phenomena--or epigenetics, by one definition--that contribute to drug addiction, with the hope that such mechanistic insights may aid in the development of novel therapeutics for future treatments of addiction.

PMID:
21272014
PMCID:
PMC3071632
DOI:
10.1111/j.1749-6632.2010.05893.x
[PubMed - indexed for MEDLINE]
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