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Org Lett. 2011 Mar 4;13(5):884-7. doi: 10.1021/ol1029386. Epub 2011 Jan 27.

Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation.

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  • 1Department of Oceanography, Kunsan National University, Jeonbuk, Korea. jrrho@kunsan.ac.kr

Abstract

Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.

PMID:
21271720
DOI:
10.1021/ol1029386
[PubMed - indexed for MEDLINE]
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