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Anal Chem. 1990 Nov 1;62(21):2258-70.

Applications of dioxetane chemiluminescent probes to molecular biology.

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MilliGen/Biosearch, Burlington, Massachusetts 01803.

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  • Anal Chem 1991 Apr 15;63(8):848.


DNA probes and synthetic oligonucleotides in general present one of the key tools in modern molecular biology research and increasingly also in commercial applications. Along with the many applications that have been developed for and with DNA probes, faster and more sensitive detection methods are being developed. One of the most promising recent developments presents a method based on enzymatically triggered chemiluminescence. Details of this chemistry along with applications in molecular biology and immunology will be discussed and compared to conventional methods.

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