Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Immunopathol. 2011 Mar;33(2):135-56. doi: 10.1007/s00281-011-0249-9. Epub 2011 Jan 27.

Lung transplantation: infection, inflammation, and the microbiome.

Author information

1
Division of Pulmonary and Critical Medicine, Department of Medicine, University of California, La Jolla, CA 92093, USA.

Abstract

Lung transplantation is the only therapeutic option for patients with end-stage pulmonary disorders. Despite the improvements in surgical techniques and immunosuppressive therapy, allograft function and long-term survival are limited by the development of chronic lung transplant rejection. In this review, we focus on bronchiolitis obliterans syndrome (BOS) which is the major manifestation of chronic lung allograft rejection. We specifically review the effect of infection, a risk factor for BOS, cytokines/chemokines in the pathogenesis of BOS, and the potential link between the allograft microbiome and immune responses that may mediate the development of BOS. Understanding the allograft microbiome and how it relates to the pathologic mechanisms of BOS may suggest targeted therapies to improve long-term survival post-lung transplantation.

PMID:
21271250
DOI:
10.1007/s00281-011-0249-9
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center