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Diabetes Care. 2011 Feb;34(2):464-7. doi: 10.2337/dc10-1734.

The prevalence and predictors of an abnormal ankle-brachial index in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

Collaborators (431)

Detre KM, Kelsey SF, Brooks MM, Orchard TJ, Thomas SB, Tyrrell KS, Rana JS, Averbach F, MacGregor JM, O'Neal SM, Pitluga K, Sansing V, Tranchine M, Crow SW, Bertolet MM, Hardison R, Kip K, Lombardero M, Lu J, Janiszewski S, Protivnak D, Reiser S, Barton S, Guo P, Kushner Y, Martin JP, Kania C, Kania M, O'Donnell J, Maxwell RA, Frye RL, Goldberg S, Rosenberg Y, Desvigne-Nickens P, Ershow A, Gordon D, Paltoo D, Jones TL, Hueb W, Ramires J, Lopes N, Wajchenberg BL, Martinez EE, Oliveira SA, Ribeiro EE, Perin M, Betti R, Schwartz L, Steiner G, Barolet A, Groenewoud Y, Mighton L, Camelon K, O'Rourke R, Blodgett J, Sako E, Nicastro J, Prescott R, Rihal C, Kennedy F, Barsness G, Basu A, Clavell A, Frye R, Holmes DR Jr, Lerman A, Mullaney C, Reeder G, Rizza R, Schaff H, Smith S, Somers V, Sundt T, Ting H, Wright RS, Helgemoe P, Lesmeister D, Rolbiecki D, Lepe-Montoya L, Escobedo J, Barraza R, Baleón R, Campos A, García P, Lezama C, Miramontes C, Ocampo S, Peñafiel JV, Valdespino A, Verdín R, Albarrán H, Ayala F, Chávez E, Murillo H, Buitrón LV, Rico-Verdin B, Angulo F, Adler D, Halle AA, Ismail-Beigi F, Paranjape S, Mazzurco S, Ridley K, Ramanathan K, Solomon S, Wall B, Weinman D, Touchstone T, Douglas L, Bourassa M, Tardif JC, Chiasson JL, Lavoie MA, Rabasa-Lhoret R, Langelier H, Foucher S, Trudel J, Monrad S, Srinivas V, Zonszein J, Crandall J, Duffy H, Vartolomei E, King S 3rd, Jacobs C, Robertson D, Porter M, Eley M, Nichols E, LaCorte J, Mock M, Rogers W, Ovalle F, Bell D, Misra VK, Hillegass WB, Aqel R, Pierce P, Smith M, Saag L, Vaughn A, Smith D, Grimes T, Rolli S, Hill R, Barrett BD, Morehead C, Doss K, Davidson CJ, Molitch M, Beohar N, Massaro E, Goodreau L, Arroyo F, Neužil P, Pavlickova L, Stehlíková Š, Benedik J, Coling L, Davies R, Glover C, LeMay M, Mesana T, Ooi TC, Silverman M, Sorisky A, Favreau C, McClinton S, Weiss M, Weiss I, Saulle L, Kannam H, Kurylas JC, Vasi L, Douglas J Jr, Ghazzal Z, Sperling L, King S 3rd, Dayamani P, Gebhart S, Basu S, Helmy T, Tangpricha V, Hyde P, Jenkins M, Grant BP, Kent K, Suddath W, Magee M, Julien-Williams P, Reed V, Nassar C, Dagenais G, Garceau C, Auger D, Buller C, Elliott T, Ramanathan K, Ricci D, Fox R, Kolesniak D, Attubato M, Feit F, Richardson S, Sing IP, Slater J, Amendola A, Vargas B, Tsapatsaris N, Woods B, Cushing G, Rutter M, Singh P, DesRochers G, Woodhead G, Gannon D, Campbell NS, Ragosta M, Sarembock I, Powers E, Barrett E, Jahn L, Murie K, Das G, Sigurdsson G, White C, Bantle J, Redmon JB, Kwong C, Tamis-Holland J, Albu J, Hochman JS, Slater J, Wilentz J, Frances S, Tormey D, Pepine C, Smith K, Kennedy L, Brezner K, Curry T, Bleyer F, Albert S, Mooradian A, Plummer S, Fuentes F, Robles R, Lavis V, Gomez J, Iliescu C, Underwood C, Fulton MS, Ramirez JG, Merta J, Scott G, Krishnaswami A, Dowdell L, Berkheimer S, Greenbaum A, Whitehouse F, Pangilinan R, Mann K, Jacobs AK, Sternthal E, Ebner S, Nedeljkovic Z, Beardsley P, Schneider D, Pratley R, Cefalu W, Schnure J, Rowen M, Tilton L, Niederman A, Mata C, Kellerman T, Farmer J, Garber AJ, Kleiman N, Howard N, Nichols D, Pool M, Granger C, Feinglos M, Adams G, Green J, Druken B, Underwood D, Stafford JL, Donner T, Laskey W, Beach D, Lopez J, Davis A, Faxon D, Reutrakul S, Bayer E, Marroquin O, Cohen H, Korytkowski M, Koerbel G, Baxendell L, Rosenfelder D, DeRiso L, Farrell C, Vita T, McGill J, Krone R, Bach R, Recklein C, Luepke KM, Clifton MJ, Farkouh ME, Kim MC, Smith DA, Guzman I, Travis A, O'Keefe J, Forker A, Isley W, Moe R, Kennedy P, Rosson M, Long A, Bates E, Herman W, Pop-Busui R, Duvernoy C, Stevens M, Luciano A, Majors C, Gottlieb SH, Rodriguez A, Herr M, Williams D, Smith RJ, Abbott JD, Laufgraben MJ, Grogan M, Muratori J, Habib G, Marcelli M, Mikati I, Cordero E, Caldwell G, Schechter D, Lorber D, August P, Brown M, Depree P, Huber K, Hanusch-Enserer U, Jordanova N, Cilesiz D, Vogel B, McCallister B Jr, Kleerekoper M, Urbanic R, Bengston J, Kong BK, Pruitt A, Sanfield J, Carulli C, Churley-Strom R, Magorien R, Osei K, Boyer CC, Lee R, Palumbo P, Wisbey J, Alderman E, Ikeno F, Schwarzkopf A, Steffes M, Nowicki M, Bucksa J, Chaitman B, Eckstein J, Stocke K, Hlatky MA, Boothroyd DB, Melsop KA, Sobel BE, Rowen M, Neimane D, Iskandrian AE, Schaaf MB, Genuth S, Bongarno T, Nesto R, August P, Hultberg K, Gottlieb SH, Albu J, Rosenhouse-Romeo H, Orchard TJ, Pambianco G, Lombardero M, Mock M, Frye RL, Brooks MM, Desvigne-Nickens P, Ershow A, Genuth S, Goldberg S, Gordon D, Hardison R, Jones TL, Kelsey S, Nesto R, Orchard T, Paltoo D, Rosenberg Y, Ryan T, Lebovitz H, Brown R, Friesinger G, Horton E, Mason J, Virmani R, Wechsler L, Bairey-Merz CN, Kennedy JW, Gordon D, Antman E, Colwell J, Fowler S, Furberg C, Goldman L, Jennings B, Rankin S.

Author information

1
Ocala and Munroe Regional Medical Center, Ocala, Florida, USA.

Abstract

OBJECTIVE:

To examine ankle-brachial index (ABI) abnormalities in patients with type 2 diabetes and coronary artery disease (CAD).

RESEARCH DESIGN AND METHODS:

An ABI was obtained in 2,240 patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. ABIs were classified as: normal, 0.91-1.3; low, ≤ 0.9; high, >1.3; or noncompressible artery (NC). Baseline characteristics were examined according to ABI and by multivariate analysis. RESULTS ABI was normal in 66%, low in 19%, and high in 8% of patients, and 6% of patients had NC. Of the low ABI patients, 68% were asymptomatic. Using normal ABI as referent, low ABI was independently associated with smoking, female sex, black race, hypertension, age, C-reactive protein, diabetes duration, and lower BMI. High ABI was associated with male sex, nonblack race, and higher BMI; and NC artery was associated with diabetes duration, higher BMI, and hypertension.

CONCLUSIONS:

ABI abnormalities are common and often asymptomatic in patients with type 2 diabetes and CAD.

PMID:
21270200
PMCID:
PMC3024368
DOI:
10.2337/dc10-1734
[Indexed for MEDLINE]
Free PMC Article

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