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Gait Posture. 2011 Mar;33(3):442-6. doi: 10.1016/j.gaitpost.2010.12.021. Epub 2011 Jan 26.

Gait patterns of patients with inclusion body myositis.

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Motion Analysis Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States.


Inclusion body myositis (IBM) is a progressive, inflammatory muscle disease that is known to cause quadriceps weakness and knee buckling during gait. This is the first known report of gait characteristics in patients with IBM. Nine subjects with IBM and quadriceps weakness underwent gait analysis and quantitative strength testing. A wide range of strength and gait abilities were present in the subject group. Subjects with stronger knee extensors exhibited nearly normal sagittal knee kinematics and kinetics. As quadriceps strength decreased, kinematic and kinetic patterns were increasingly abnormal. Exceptions to this pattern could be explained by examining strength at adjacent joints. Gait analysis and strength testing is a helpful tool in evaluating the functional status of this population and aiding in determination of the needs for interventions such as assistive devices.

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