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Clin Nephrol. 2011 Feb;75 Suppl 1:32-6.

Collapsing glomerulopathy in a patient with mixed connective tissue disease.

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1
Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA. srifkin@health.usf.edu

Abstract

Collapsing glomerulopathy (CG) is a distinct clinicopathological entity characterized by glomerular capillary collapse, podocyte proliferation, diffuse mesangial sclerosis, and podocyte maturation arrest. Initially noted primarily in HIV infected patients, a number of other diseases have now been associated with CG. Mixed connective tissue disease (MCTD) is a disease with overlapping features of systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis. It was originally thought that renal involvement was a rare complication of MCTD. However, over the years, it has become clearer that renal involvement, although not always clinically apparent, is frequent. In this report we present a patient with MCTD who developed CG.

PMID:
21269591
[Indexed for MEDLINE]
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