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Anat Cell Biol. 2010 Dec;43(4):269-79. doi: 10.5115/acb.2010.43.4.269. Epub 2010 Dec 31.

Control of neuronal migration through rostral migration stream in mice.

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1
Department of Anatomy and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, Korea.

Abstract

During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located near the ventricle, and the newly generated cells actively migrate toward their destination, olfactory bulb, via highly specialized migratory route called rostral migratory stream (RMS). Neuroblasts in the RMS form chains by their homophilic interactions, and the neuroblasts in chains continually migrate through the tunnels formed by meshwork of astrocytes, glial tube. This review focuses on the development and structure of RMS and the regulation of neuroblast migration in the RMS. Better understanding of RMS migration may be crucial for improving functional replacement therapy by supplying endogenous neuronal cells to the injury sites more efficiently.

KEYWORDS:

Adult neurogenesis; Neuroblasts; Neuronal migration; Rostral migratory stream

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