Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2011 Feb;11(2):119-30. doi: 10.1038/nri2916.

Phenotypical and functional specialization of FOXP3+ regulatory T cells.

Author information

1
Immunology Program, Benaroya Research Institute, Seattle, Washington 98103, USA. campbell@benaroyaresearch.org

Abstract

Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells prevent autoimmune disease, maintain immune homeostasis and modulate immune responses during infection. To accomplish these tasks, T(Reg) cell activity is precisely controlled, and this requires T(Reg) cells to alter their migratory, functional and homeostatic properties in response to specific cues in the immune environment. We review progress in understanding the diversity of T(Reg) cells, T(Reg) cell function in different anatomical and inflammatory settings, and the influence of the immune environment on T(Reg) cell activity. We also consider how these factors affect immune-mediated disease in the contexts of infection, autoimmunity, cancer and transplantation.

PMID:
21267013
PMCID:
PMC3289970
DOI:
10.1038/nri2916
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center