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FEBS Lett. 2011 Feb 18;585(4):671-6. doi: 10.1016/j.febslet.2011.01.030. Epub 2011 Jan 23.

Control of RNA processing by a large non-coding RNA over-expressed in carcinomas.

Author information

1
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. ruilin2005@gmail.com

Abstract

RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.

PMID:
21266177
PMCID:
PMC3065235
DOI:
10.1016/j.febslet.2011.01.030
[Indexed for MEDLINE]
Free PMC Article

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