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Nano Lett. 2011 Feb 9;11(2):808-13. doi: 10.1021/nl104117p. Epub 2011 Jan 25.

Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings.

Author information

1
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

Abstract

Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.

PMID:
21265552
PMCID:
PMC3122105
DOI:
10.1021/nl104117p
[Indexed for MEDLINE]
Free PMC Article

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