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Glia. 2011 Mar;59(3):472-85. doi: 10.1002/glia.21117. Epub 2010 Dec 29.

Microglia/macrophages promote glioma progression.

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1
Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York 11794-8651, USA.

Abstract

Gliomas are highly aggressive and accompanied by numerous microglia/macrophages (MG/MP) in and about the tumor. Little is known about what MG/MP do in this setting, or whether modulating MG/MP activation might affect glioma progression. Here, we used a glioma-microglia in culture system to establish the effects the tumor and microglia have on each other. We assessed glioma progression in vivo after MG/MP ablation or in the setting of exaggerated MG/MP activation. We show that glioma cells activate microglia but inhibit their phagocytic activities. Local ablation of MG/MP in vivo decreased tumor size and improved survival curves. Conversely, pharmacological activation of MG/MP increased glioma size through stimulating tumor proliferation and inhibiting apoptosis. In agreement with recent reports, expression of the chemokine CCL21 is enhanced after MG/MP activation and correlates with tumor growth. Taken together, our findings demonstrate that inhibition of MG/MP activation may constitute a new and effective contribution towards suppressing glioma proliferation.

PMID:
21264953
PMCID:
PMC3080032
DOI:
10.1002/glia.21117
[Indexed for MEDLINE]
Free PMC Article
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