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Chin J Dent Res. 2010;13(2):153-6.

Saponins from Plumeria acuminata Ait induce cell growth inhibition and apoptosis of oral squamous carcinoma cells.

Author information

1
Oral Medical Department, Faculty of Dentistry, University of Gadjah Mada, Yogyakarta, Indonesia. drghendri@ugm.ac.id

Abstract

OBJECTIVE:

to investigate the cytotoxic and apoptotic effects of saponins from Plumeria acuminata Ait on oral squamous carcinoma cells (OSCC).

METHODS:

OSCC cells seeded at 2 × 104 cells/well in a 96-well plate were treated with saponins from P. acuminata Ait and cisplatin in various concentrations for 24 h. Trypan blue dye exclusion assay and ethidium bromide/acridine orange were used to evaluate their cytotoxic and apoptotic effects on the cells, respectively.

RESULTS:

the results showed that both saponins and cisplatin had cytotoxic and apoptotic effects on OSCC cells.

CONCLUSION:

saponins from P. acuminata Ait may be potential anti-cancer agents for OSCC.

PMID:
21264367
[Indexed for MEDLINE]
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